Manchester United could have up to 10 players out for their trip to Crystal Palace on Wednesday evening.
In Sunday's goalless stalemate with Liverpool - Ander Herrera, Juan Mata and Jesse Lingard were taken off due to injuries.
Marcus Rashford was forced to play the rest of the game with an injury picked up in the first-half to his ankle.
Nemanja Matic and Anthony Martial were both forced to miss out at Old Trafford, with Phil Jones, Matteo Darmian and Antonio Valencia also unavailable.
17-year-old Mason Greenwood is also out injured for Ole Gunnar Solksjaer's men, with the United interim boss admitting his options are very limited for the trip to Selhurst Park.
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"We've not had a session yet, so I do not think there are a lot of positives, no," Solksjaer admitted.
"I don't know the list (of players) that is supposed to be injured, Matteo (Darmian) trained the other day. I don't think he'll be ready.
"(Marcos) Rojo will be involved. Rashford we're still waiting to see how his ankle is responding to the treatment, muscle injuries are too early to think about. That's it.
"Phil (Jones) was ill one of the days last week, so he's been out for a while as well with an illness.
"Luckily at centre-back, there are quite a few fit ones, Victor (Lindelof), Chris (Smalling) and Eric (Bailly), the three of them are ready."