Southampton held on for a 2-1 win despite playing half of the game with 10 men against Leicester City to pile even more pressure on Claude Puel.
James Ward-Prowse scored a penalty to give Saints an early lead just over 10 minutes in and Shane Long made it two just after Yan Valery was red carded for two yellow cards.
Wilfred Ndidi offered a reply for Leicester in the second-half, but Southampton held on for a huge victory at the King Power Stadium.
Ward-Prowse converted an 11th minute penalty to open the scoring in Leicester (image via Premier League).
Long was taken down by Nampalys Mendy just inside the area and Michael Oliver awarded the spot-kick. Ward-Prowse fired into the top corner.
Leicester were struggling to create anything noteworthy offensively; and their first shot on goal was registered on the half-hour mark.
Jack Stephens was the man with the shot, denied by a flying save from Kasper Schmeichel.
It seemed as if the Foxes had found a route back into the game - starting to play well and then Valery was shown a second yellow card for a foul on Marc Albrighton.
However, with Valery not even down the tunnel yet; Ricardo Pereira was caught sleeping and Long fired home to double Southampton's advantage.
Leicester dominated possession in the second-half, but their attacking players couldn't get the final ball right.
Pereira set up Ndidi, who bundled home with 32 minutes remaining, and Southampton then held out for a huge victory at the King Power.
The Managers
Leicester City boss Claude Puel: "We wanted to perform, we wanted to have a reaction and our concentration was perhaps too much. It was a difficult scenario.
"We didn't manage the first-half well. It would have been good to have come back without the second goal but it was harsh and it was a bad moment.
"We played with desire and intensity in the second-half but we didn't perform enough."
Southampton manager Ralph Hasenhuttl: "We had to be compact in the second-half and try to defend everything.
"I think the manner of the performance was good, showing passion.
"When they made it 2-1 I thought it would be too long for us to hold on. But the way we defended made it very difficult for the opposition to score. The longer the game went on, the steadier and more balanced we were. That was the key to the success."