Both Southampton and Everton will be determined to build some momentum following their wins last weekend, as they battle it out at St. Mary's.
The Saints were victorious, as they held on to a 2-1 lead against Leicester City despite having a man disadvantage.
Everton comfortably beat Bournemouth 2-0 on Sunday, as they ended their Premier League drought.
These two teams battled it out in August of 2018, with Everton racing to a 2-0 lead through Theo Walcott and Richarlison. Danny Ings' reply in the second-half proved pointless as the Toffees held on at Goodison Park.
Image via Alex Livesey/Getty Images Sport
Team News
Southampton are set to welcome back Emile Hojbjerg, Yan Valery and Charlie Austin, who have now all served their respective suspensions.
Danny Ings is available for selection, with the on-loan striker recovered from a thigh injury.
However, Ryan Bertrand, Shane Long and Mario Lemina are doubts for the hosts, and Michael Obafemi has been ruled out.
Everton winger Ademola Lookman could make consecutive league starts for the first time this season.
Phil Jagielka is out, though, with an injury he sustained in a training session this week.
The Managers
Southampton boss Ralph Hasenhuttl: "Every win is very important at the moment. We showed against Leicester how much we wanted to fight for the three points, because we knew exactly that it could help us to leave the relegation zone.
"The next opponents after Saturday - Crystal Palace, Burnley and Cardiff - are teams that are in our zone. This game on Saturday and then the next ones maybe show us in what direction our development is going - is it going in the upper regions or do we stay where we are?"
Everton manager Marco Silva on whether any additions will be brought in, in January: "When you asked me the last few weeks the possible players coming in or not in the market, I told you that you can't just sign someone if someone leaves the club or we sell someone.
"We don't have the financial conditions to go in the market, (that) is the feedback I have at the moment. I have to find different solutions."
Match Stats
- Everton have won just three of their 19 Premier League matches at St. Mary's (D6, L10).
- If Everton win on Saturday, it will be their first league double over the Saints since 2001-02.
- The Saints have just one clean sheet in their past 12 Premier League games.
- Shane Long scored his first goal since April last weekend, and he is now short of 50 goals in the Premier League.
- Everton full-back Lucas Digne has crossed the ball in 102 times this season in the league - at least 21 more than any defender in the division.
Betting Odds
Southampton: 7/4
Draw: 12/5
Everton: 17/10