A Lucas Moura masterclass piles the pressure on Manchester United and Jose Mourinho.
Hugo Lloris, to some people's surprise kept the captain's armband for the visitors, despite his drink-driving charge last week.
The first-half started lively and tailed off a bit towards the middle and latter stages, with the hosts having more of the ball and edging possession.
The first big chance of the half fell to United as well, and Romelu Lukaku - a poor Danny Rose backpass was latched onto by the Belgian, who rounded Lloris but couldn't find the empty net.
Spurs were denied a penalty, when Lucas Moura did some good work - and Phil Jones appeared to take him down but the referee was having none of it.
Lucas was very impressive in the first-half for Spurs - probably still buzzing from opening his account for the club last week against Fulham.
The teams went into the half-time break at 0-0, with United definitely having the better of the first-half with some good chances.
However, Mauricio Pochettino's team were growing into the game as the half went on and the likes of Dele Alli, Lucas Moura and Harry Kane were looking dangerous on the break for the visitors.
I said they were looking dangerous and they stunned Old Trafford early into the second-half.
Kieran Trippier's corner was met by the head of Kane, who had a free header and unsurprisingly put it beyond David de Gea, to give Spurs the lead.
A couple of minutes later, it was 2-0 to the visitors and their standout performer scored his second goal in as many games; Lucas Moura.
A counter-attack ended up at Christian Eriksen's feet, whose low cross was met by a determined Moura who doubled his side's tally and it was an uphill battle for Mourinho.
United's manager immediately responded by bringing Alexis Sanchez on and Victor Lindelof about a minute later.
Jesse Lingard had a great opportunity for United to half the deficit, but Toby Alderweireld, who was linked heavily with the hosts in the summer, produced a vital clearance.
Alli had the chance to completely put the game beyond United's reach, when a Lindelof pass was underhit to de Gea and the English international rounded the Spaniard, but the 'keeper did well to get back and save Alli's effort.
From the resulting corner, Kane had a golden chance - again, some suspect marking from Lindelof, who hadn't had the best minute or so, but the striker couldn't add his second.
United kept trying to create chances, and did produce a couple; but the pressure wasn't enough to concern Tottenham's brilliant centre-back partnership of Alderweireld and Jan Vertonghen.
The two Belgians were excellent today and completely proved their worth to this Tottenham side.
Lucas put the game to bed with five minutes to go, with a brilliant solo goal - he got the better of Chris Smalling with some great skill before powering it past de Gea.
The Brazilian was definitely the standout man for Tottenham as they won for the first time in four years at Old Trafford.
The chants of "You're getting sacked in the morning" ringing around the stadium at the end of the game were very telling of the story.
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