Manchester City will have the chance to take over leaders Liverpool, before the Reds have even kicked a ball, as they travel down to Crystal Palace.
City are two points behind the Reds, who lead the way, but have played a game more than the reigning champions.
Pep Guardiola's side were actually victims of a defeat to Palace when the sides met in the reverse fixture this season - oh, how Liverpool fans would love a repeat of that...
TEAM NEWS
Crystal Palace defender James Tomkins will be sidelined for the remainder of the season after hurting his groin at Newcastle United.
Fellow defender Mamadou Sakho remains out of the squad with a knee issue, but Max Meyer is back and available after a virus.
Manchester City midfielder Bernardo Silva missed the loss at Tottenham in the Champions League, and will undergo a late fitness test on his thigh.
Oleksandr Zinchenko has been out of the last two matches with a hamstring injury, will be monitored as well.
Full-back Benjamin Mendy could make his first start for FIVE months, with Kevin de Bruyne and Leroy Sane expected to be recalled.
THE MANAGERS
Crystal Palace manager Roy Hodgson: "It's a dangerous thing to say you are safe until it's mathematically true. The teams below us would have a lot to do to catch us, though.
"We are capable of beating every other team in this league. When you've been in the league for six seasons and looking to embark on your seventh, you can call yourself established."
Manchester City boss Pep Guardiola: "Selhurst Park is always difficult because of the stadium and the quality of the (Palace) players.
"Roy Hodgson is an experienced manager (who has worked in) a lot of different countries, he knows how to handle these situations. Nobody felt he could stay up last season and he did it, and he's doing the same this season."
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